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醫(yī)藥研發(fā)求職簡歷模板使用便捷-高效-實用，高效提升求職效率，做高質量簡歷就用錘子簡歷。

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? 頭像: 隱藏

編輯

["sex","age","nation","education","marriageStatus","politicalStatus","city","jobYear","mobile","email"]

? 基本信息: 女

26歲



本科





?

3年經驗

13800138000

BD@100chui.com

 技能特長: 執(zhí)行能力精通

溝通能力精通

學習能力精通

+

? 姓名: 錘子簡歷

世界屬于那些勤于思考的人，更屬于那些善于行動的人。

 求職意向: 
醫(yī)藥研發(fā)


廣州


面議


隨時到崗

 教育背景: 2014年9月 - 2018年6月

錘子簡歷大學

計算機與信息技術

GPA：3.72/4
GRE：324

 工作經驗

2019.03 - 至今

錘子簡歷信息有限公司

醫(yī)藥研發(fā)

負責從PBMC中分選T細胞和Monocyte，并將Monocyte刺激分化巨噬細胞和樹突狀細胞。
負責進行ADCP實驗，利用FACS檢測抗體依賴的巨噬細胞吞噬效應。負責實驗計劃和實驗結果分析總結。負責工具細胞株構建。
負責TAM的免疫抑制信號通路如SIRPa- -CD47，Siglec10- -CD24，PD1- -PDL1等的專利和文獻調研。

2018.03 - 2019.03

錘子簡歷科技有限公司

醫(yī)藥研發(fā)

雜交瘤抗體細胞庫的建立和鑒定，雜交瘤抗體陽性細胞株表面受體量的表達檢測及定量;
Fortebio、ELISA實驗體系的開發(fā)，驗證，以及與CRO公司方法的轉移;
2"ADC細胞殺傷性實驗體系的開發(fā)及驗證，以及陽性抗體的篩選;
雜交瘤陽性高表達細胞株的篩選，培養(yǎng)，上清收集及凍存；陽性抗體親和力的測定-ELISA: EC50和Fortebio: KD;
雜交瘤陽性抗體提取CDR區(qū)域，以及人源化；嵌合抗體和人源化的抗體理化性質的鑒定和分析;
抗體Epitobe競爭實驗方法的開發(fā)方法；抗體功能學實驗的開發(fā)及實驗步驟的確定; ADCC, CDC，細胞的凋亡和周期，細胞的內吞實驗等等;

 項目經驗

2021.03 - 2021.06

項目工程

醫(yī)藥研發(fā)

項目描述：從近200個靶向BCR- -ABL的PROTAC小分子中，篩選到了多個能夠降解BCR- -ABL蛋白的小分子,其在靶標，細胞水平均表現出很好的生物學活性和選擇性。本人參與完成了蛋白降解靶向BCR-ABL化合物及其抗腫瘤應用的專利撰寫和專利申請。最后從降解效果較好的化合物中選取了一個先導化合物進行了動物實驗藥效學和作用機制方面研究。
責任描述：蛋白質免疫印跡Western-blot測定PROTAC蛋白降解化合物對慢性粒細胞白血病細胞降解效果測定;
利用定點突變技術，構建臨床耐藥細胞株，并利用真核轉染技術體外表達后流式細胞術分選耐藥細胞株;
利用免疫共沉淀技術研究蛋白的相互作用;利用蛋白質組學研究了PROTAC藥物其他蛋白的降解效果影響的研究，利用激酶組學測定了PROTAC藥物對激酶的影響;也測定了先導化合物的藥物的透膜性;
利用CDX動物模型在NOD- -SCID人源化小鼠中對先導化合物進行抗白血病的體內效果研究;

 自我評價: 本人對待工作踏實，認真，并且極富工作和團隊精神，因此在工作和生活中結交了許多朋友，具有良好的適應性和熟練的溝通技巧，相信能夠協(xié)助主管人員出色地完成各項工作。忠誠穩(wěn)重堅守誠信正直原則，勇于挑戰(zhàn)自我開發(fā)自身潛力。感謝您在百忙之中閱覽我的簡歷，靜候佳音！